Clenbuterol Hydrochloride 40mcg

Composition: 
Each tablet contains: 
Clenbuterol Hydrochloride BP 40 mcg 

Clinical Pharmacology: 
Clenbuterol exerts a pronounced action on the metabolism; with both anabolic and anti-catabolic effects. Clenbuterol has been demonstrated to increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio. 
Clenbuterol is a beta-2 adrenergic agonist relaxing airway muscle tissue and proving bronchodialation. Clenbuterol increases aerobic capacity, pulse perspiration and blood pressure; increases basal metabolic rate and temperature. 
Clenbuterol has an oral bioavailability of 89 to 98 % with a half- life of 36 to 48 hours after oral use. 

Indication: 
To increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio in human. 

Contraindication: 

1. Children or geriatric patients 
2. Individuals who have been diagnosed of cardio-vascular problems should not take Clenbuterol. 
3. Women who are pregnant or may become pregnant 
4. Concomitantly with other CNS stimulants, adrenergic, or hypertensive agents 
5. In patients with hypersensitivity to Clenbuterol or other ingredients 
6. In patients with a history of GI bleeding, ulceration of the stomach, or gastritis 

Precautions: 
Clenbuterol can produce significant cardiovascular effects in some patients as evidenced by elevated pulse rate, blood pressure changes and or ECG changes. The patients who use Clenbuterol should be monitored for changes in heart rate, arterial blood pressure and or oxygen saturation of arterial blood. Urticaria and tachycardia may be observed during the few first days of treatment; if this occurs; discontinue and consult physician immediately. 
Not for use by nursing mothers due to unknown effect from excreted milk. 

Use in pregnancy: 
Although animal experiments showed no teratogenic effects. 
Clenbuterol should not be used during the 1 • trimester of pregnancy because of its labour inhibiting action and it should not be taken shortly before childbirth. 

Drug Interaction: 
Clenbuterol may enhance the action and side effects of other beta -adrenergic rn.imetics, theophylline and anti- cholinergic. 
Beta blockers may inhibit the action of Clenbuterol; thus a risk of bronchospasm exists with concomitant uses. 
Clenbuterol may alter the action of hypoglycemic agents, insulin sensitizers, insulin and insulin secretagogues. Adjust of dosage may be required. Monitor for loss of glycaemic control. 
There is an increased risk of arrhythmia with concomitant administration of halogenated carbohydrates for nacrosis; e.g. during surgery. Concomitant use with diuretics and digitalis glycosides requires periodic monitoring of serum electrolytes. 
Concomitant use with other CNS stimulants should be avoided given the cumulative stimulatory effects and increased risk of adverse events. 
Concomitant use with MAO- inhibitors and tri- cyclic antidepressant may produce cardiac dysrhythmias.